Sap & Extract

Flaxseed hull Extract Lignans 20% ~80% SDG.

DESCRIPTION

Secoisolariciresinol diglycoside, or SDG, is a plant lignan most notably found in flaxseed (linseed). SDG is classified as a phytoestrogen since it is a plant-derived, nonsteroid compound that possesses estrogen-like activity. SDG has weak estrogenic activity. The level of SDG in flaxseed typically varies between 0.6% and 1.8%.

Lignans are one of the two major classes of phytoestrogens; The other class is the isoflavones. Plant lignans are polyphenolic substances derived from phenylalanine via dimerization of substituted cinnamic alcohols. Mammalian lignans are lignans derived from plant lignans. For example, following ingestion, SDG is converted to the aglycone secoisolariciresinol, which is then metabolized to the mammalian lignans enterolactone and enterodiol. Most of the effects of oral SDG are mediated by enterolactone and enterodiol.

The molecular formula of SDG is C32H46O16, and its molecular weight is 686. 71 daltons. The aglycone of SDG is also known as 2, 3-bis (3-methoxy-4-hydroxybenzyl) butane-1, 4-diol. Enterolactone is also known as trans-2, 3-bis [(3-hydroxylphenyl) methyl]-butyrolactone.

ACTIONS

SDG has estrogenic and antioxidant activities. It may also have antiestrogenic, anticarcinogenic, antiatherogenic and antidiabetic activities.

MECHANISM OF ACTION

SDG, as well as its mammalian lignan metabolites, enterolactone (EL) and enterodiol (ED), have weak estrogenic activity as measured in in vivo and in vitro assays.

SDG, EL and ED have a number of antioxidant activities, including inhibition of lipid peroxidation and scavenging of hydroxy radicals. SDG also has anti-platelet-activation factor (PAF) activity. PAF can induce the release of reactive oxygen species from neutrophils. SDG, via its metabolite EL, has been found to inhibit estrogen synthase (aromatase) and to stimulate the synthesis of sex hormone binding globulin (SHBG). Both of these actions could account for the possible anti-estrogen activity of SDG.

The possible anticarcinogenic, antiatherogenic and antidiabetic activities of SDG are thought to be due, in large part, to the antioxidant activities of its metabolites EL and ED.

PHARMACOKINETICS

SDG, following ingestion, is transported to the large intestine, where it is hydrolyzed by bacteria to the aglycone secoisolariciresinol. Secoisolariciresinol, in turn, is metabolized by bacteria in the large intestine to the mammalian lignans EL and ED. EL and ED are absorbed from the large intestine. Little is known about the distribution of EL and ED to the various tissues of the body. It is known that ED and EL undergo conjugation in the liver with glucuronate and sulfate. The glucuronate and sulfate conjugates of ED and EL are excreted in the urine and in the bile.

There appears to be considerable individual variation in the absorption and metabolism of the SDG metabolites ED and EL.

INDICATIONS AND USAGE

There is evidence in in vitro and animal research that SDG may have some ability to reduce cholesterol levels and protect against atherosclerosis; It may also have some anticancer and antidiabetic effects.

RESEARCH SUMMARY

Rabbits fed a high-cholesterol diet supplemented with flaxseed had 46% less atherosclerotic development than rabbits fed the same diet without flaxseed. Still better results were obtained (73% reduction in atherosclerosis) when the diet was supplemented with SDG instead of flaxseed. These effects were associated with reduced serum levels of cholesterol and LDL-cholesterol and increased levels of HDL-cholesterol.

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AIGI supply Giant Knotweed Extract Resveratrol 10%~98%

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Product Specification: Resveratrol 10%~98%

Latin Name: Polygonum Cuspidatum

Product Type: White powdered extract

Part of the Plant Used: Root

Extract Method: Alcohol

What is the Giant Knotweed Extract?

Giant knotweed is an east Asian species (Polygonum cuspidatum), belonging to the Polygonaceae family. Documented uses in traditional Chinese medicine date to the first century BC, and contemporary medical uses supported by clinical results include acute microbial infections or viral hepatitis, chemo- or radiation-induced leukocytopenia, atherosclerosis, and hyperlipidemia.

Giant knotweed extract has exhibited antitussive, antihistaminic, hypotensive, vasodilating, cytotoxic, and antioxidant properties, among others. Giant knotweed extract is also a concentrated source of resveratrol, an antioxidant phenol produced in response to fungi. Resveratrol has also shown antimutagenic activity in bioassays conducted on bacteria in vitro. And, in a recent investigation conducted in vivo and in vitro, resveratrol displayed chemopreventive effects at three critical stages of carcinogenesis.

Specifically, resveratrol was found to

1) induce phase II drug metabolizing enzymes;

2) mediate anti-inflammatory effects and inhibit cyclooxygenase and hydro-peroxidase (antipromotion);

3) induce human promyelocytic leukemia cell diferentiation. Resveratrol was also found to inhibit the development of preneoplastic lesions in vitro and tumorigenesis in vivo. Very recently, it was reported that Giant knotweed extract is one of the best active-oxygen scavengers for the prevention of skin aging induced by UV-irradiation and free radical. Experiments conducted in vivo indicate that resveratrol is a potent vasodilator and inhibitor of platelet aggregation. Recent work in dogs and humans indicate that other concentrated sources of resveratrol eliminate cyclic blood-flow reductions caused by platelet-mediated thrombosis.

Where will be Giant Knotweed Extract used to?

Anti-lipid oxidation

Heart disease prevention

Anti-carcinogen

Anti-platelet aggregation

Smoothes blood vessels

Decreases blood lipid

Packing Detail

Packed in paper-drums and two plastic-bags inside. Net Weight: 25kgs/drum. I.D.40CmX50CM

Storage Situation

Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.

Shelf Life

Two years under well Storage situation and stored away from direct sun light.

Changsha Active Ingredients Group, Inc. (AIGI) is one of the leading manufacturer and exporter of the tea & herbal extracts in China, is the board of director of HNBEA (Hunan Botanical Extracts Association of China), AIGI having certified ISO9000: 2000, Kosher, cGMP.

We have been manufacturing of exporting such products as Green Tea Extracts and Natural Botanical Extracts Series. Our major standardized products are Resveratrol 99%, Magnolia Bark Extract 95%, Baicalin 95%, Blueberry juice Concentrate Brix 65, Green Tea Extract 60% EGCG, Luo Han Guo Extract 80%. Mogrosides and Effective Component Monomer product such as Huperzine A 99%, Paclitaxel 99%, Artemisinine 99%, Rhynchophylline 98% and so on. We can supply about 240 kinds of Standardized Herbal Extracts and more 900 kinds of Botanical Extracts.

Our products are in great demand and being exported to over 40 countries throughout the world.

AIGI supply Magnolia Bark P.E.(Magnolol+Honokiol 90%HPLC)

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Product Specification:Magnolol+Honokiol 90%

Latin Name:Cortex Magnoliae Officinalis

Product Type:White powdered extract

Part of the Plant Used:Bark

Extract Method:Ethyl Acetate

What is the Magnolia Bark P.E.?

Magnolia bark is used as a general anti-stress and anti-anxiety agent - so its claims typically center on general benefits in controlling stress and anxiety.Newer claims are emerging, however, to link magnolia's anti-stress benefits with control of the body's primary stress hormone, cortisol, and the myriad health benefits associated with normal cortisol levels (versus elevated cortisol, which has been associated with obesity, diabetes, osteoporosis, memory problems and suppressed immune function).

Magnolia bark is rich in two biphenol compounds, (magnolol and honokiol), which are thought to contribute to the primary anti-stress and cortisol-lowering effects of the plant.The magnolol content of magnolia bark is generally in the range of 2-10 percent, while honokiol tends to occur naturally at 1-5 percent in dried magnolia bark.Magnolia bark also contains a bit less than 1 percent of an essential oil known as eudesmol, which is classified as a triterpene compound, and may provide some additional benefits as an antioxidant

No significant toxicity or adverse effects have been associated with traditional use of magnolia bark - but because high doses can cause drowsiness, you might want to hold off on operating that bulldozer or other heavy machinery while you're easing your anxiety with magnolia bark.

Where will be Magnolia Bark P.E.Used to?

Anti-stress

Anti-anxiety

Anti-cancer

Strong antioxidants

Inhibits bacteria and pathogenic fungi

Packing Detail

Packed in paper-drums and two plastic-bags inside.Net Weight:25kgs/drum.I.D.40CmX50CM

Storage Situation

Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.

Shelf Life

Two years under well Storage situation and stored away from direct sun light.

AIGI supply Garcinia Cambogia P.E.60% HCA

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Product Specification:60% HCA

Latin Name:Garcinia Cambogia.

Product Type:Fine gray white powdered extract

Part of the Plant Used:Fruit

Extract Method:Grain Alcohol/Water

What is Garcinia Cambogia extract?

Hydroxycitric acid (HCA), is the active ingredient extracted from the rind of a little pumpkin-like fruit, Garcinia cambogia, from India and Southeast Asia.Dietary supplements and a wide variety of weight loss formulas, contain Garcinia extract to inhibit fat production and suppress appetite.A number of products include extracts (about 50% HCA) under the brand names Citrin (Sabinsa) and CitriMax (InterHealth) and a new one called Regulator is a 98% pure potassium HCA from a small Irish supplement company.

HCA can inhibit an enzyme in cells, citrate lyase, which is needed for the conversion of carbohydrates into fat.In the cell, carbohydrates are broken down into citrate compounds, which are then converted (by citrate lyase) into another compound;Acetyl coenzyme A (acetyl CoA) the metabolic building block for fat synthesis.By blocking the conversion of citrate into acetyl-CoA, HCA can suppress fat synthesis.Acetyl CoA is further converted into malonyl CoA, a compound which may block the actions of carnitine acyltransferase in shuttling fatty acids into the mitochondria to be burned.It is important to note, however, that the citrate lyase enzyme, is only significantly active under conditions of carbohydrate overconsumption.In others words, unless youre eating a lot of carbohydrate-type foods (bagels, pasta, potatoes), and overloading your carbohydrate storage capacity (muscle and liver glycogen stores) there is no significant conversion of carbohydrates into fatty acids anyway (and HCA may not work for you).If, however, youre chowing down on low-fat high-carb foods at every meal, then your glycogen stores will be over-flowing and your citrate lyase enzymes are going to be working over time converting those excess carbs to fat.OK, so now that youve blocked the fat production, you have to do something with those excess carbs.They cant be stored as glycogen because those stores in liver and muscle are already full, so it is thought that the body disposes of them by increasing carbohydrate oxidation (burning them).As a result of these fully loaded glycogen stores, some researchers have suggested that a "side effect" of HCA supplementation may be a suppression of appetite which would reduce food intake and promote weight loss.

There are no serious adverse side effects associated with intake of Garcinia cambogia or hydroxycitric acid supplements aside form some minor gastrointestinal distress induced by high doses.

Where will be Garcinia Cambogia extract used to?

Promotes weight loss

Suppresses appetite

Reduces blood lipids

Increases fat oxidation/mobilization

Promotes glycogen synthesis

Increases energy levels

Packing Detail

Packed in paper-drums and two plastic-bags inside.Net Weight:25kgs/drum.I.D.40CmX50CM

Storage Situation

Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.

Shelf Life

Two years under well Storage situation and stored away from direct sun light.

AIGI supply Soy bean Extract 40% Isoflavones

Profile:

Product Specification : 40% Isoflavones

Product Type:yellow powdered extract

Part of the Plant Used: bean

Extract Method: Alcohol

What is the Soy bean Extract?

Depending on the method of processing, many soy foods contain a relatively high content of chemical compounds called isoflavones, which possess weak estrogen-like effects. Under conditions of high estrogen exposure, which may promote certain cancers, the isoflavone compounds tend to block the adverse effects of estrogen and may prevent growth of cancer cells. Under conditions of low estrogen exposure, such as during menopause, the isoflavones tend to act as weak estrogens, which may be just enough to help alleviate some of the symptoms associated with menopause, such as hot flashes, headaches and mood swings.

As a high quality protein source, soy-based protein powders provide an excellent amino acid profile along with the added health benefits for heart health, cancer protection, bone maintenance and, in postmenopausal women, relief from menopausal symptoms. For those women who cannot or choose not to select hormone replacement therapy following menopause, isoflavone supplements may provide an effective alternative to treating some of the symptoms associated with menopause, including hot flashes, night sweats, headaches, vaginal dryness and mood swings.

Where will be Soy bean Extract used to?

Reduces cholesterol and triglyceride levels Reduces risk of heart disease

Suppresses menopausal symptoms (hot flashes)

Reduces bone breakdown (osteoporosis)

Packing Detail

Packed in paper-drums and two plastic-bags inside. Net Weight: 25kgs/drum. I.D. 40CmX50CM

Storage Situation

Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.

Shelf Life

two years under well Storage situation and stored away from direct sun light.

Changsha Active Ingredients Group, Inc.(AIGI) is one of the leading manufacturer and exporter of the tea & herbal extracts in China, is the board of director of HNBEA (Hunan Botanical Extracts Association of China), AIGI having certified ISO9000:2000, Kosher, cGMP. We have been manufacturing of exporting such products as Green Tea Extracts and Natural Botanical Extracts Series. Our major standardized products are Resveratrol 99%, Magnolia Bark Extract 95%, Baicalin 95%, Blueberry juice Concentrate Brix 65, Green Tea Extract 60% EGCG, Luo Han Guo Extract 80% .Mogrosides and Effective Component Monomer product such as Huperzine A 99%, Paclitaxel 99%, Artemisinine 99% , Rhynchophylline 98% and so on. We can supply about 240 kinds of Standardized Herbal Extracts and more 900 kinds of Botanical Extracts. Our products are in great demand and being exported to over 40 countries throughout the world.

Enclosed a brief product list as following for your reference.

1.Tea Extracts:Green tea catechins 20% ~ 90%;Green tea polyphenols 20% ~ 98%;Green tea L-theanine 20% ~ 35%;Green tea saponins 50% ~ 70%;Green tea EGCG 10% ~ 98%;Green tea ECG 90%, 95%;Pu Erh tea polyphenols 30% ~ 50%;Jasmine tea polyphenols 20% ~ 50%;Oolong tea polyphenols 20% ~ 90%;Black tea Theaflavins 20% ~ 40%;White tea extract polyphenols 30% ~ 90%

2.Herbal Extracts:

5-HTP 95%, 99%, Adenophora 10:1 Extract Agrimory 12:1 Extract Aiye Leaf 4:1 Extract Akebia Caulis 10:1 Extract Alfalfa 5% total Flavonoids (HPLC), 5:1 Extract Alisma 20:1 Extract Alisol B Acetate (HPLC) Almond 4:1 Extract Althaea Rosae Root 7:1 Extract Amlisa 30% Tannins Anemarhenae Asphodeliodes 4:1 Extract Angelica/Dong Quai 4:1Extract, 1% Ligustilides (HPLC)

Wild Ginger 10:1 Extract

Ashwagandha 1.5% Alkaloids

Asparagus Root 4%, 10% Asparagosides (UV-VIS) Astragalus P.E.0.2% Flavone/16% Polysacchrides Astragalus Root 16% Polysacchrides (UV-VIS)

Barley Grass Juice Powder 20:1 Extract Barley Grass Straight Powder 1:1 Extract Bee Propolis Straight Powder 1:1 Extract Bilberry 25% Anthocyanidins (UV-VIS) Bitter Melon 20:1 Extract, 400 IU Bitter Sophora Root 20% Matrines Black Bean 15:1 Extract Black Cohosh 2.5% Triterpene glycosides (HPLC) Black Tea 30%-40% Polyphenols (UV-VIS) Boewellia Sorrata 65% Boewellic Acids Bupleurum 5% Bupleuruum saikosaponins (UV-VIS) Burdock Root 4:1 Extract Burdock Seed 40% Arctiin & Arctigenin

Carrot Juice 20:1 Extract Cassia Fistula 1.5% Anthraquinones Cassia Nomame 10:1Extract Cassia Tora 10:1 Extract Cat Nut 4:1 Extract Cats Claw 4% Alkaloids Celandine 2% Chelidonine Chanomile 4:1 Extract Chasteberry 5% Vitexin (HPLC) Chrysanthemum 12:1 Extract Cinnamon Bark 20:1 Extract Citrus Aurantinum 4% - 30% Synepherin (HPLC) Codonopsis Root 4:1 Extract Cordyceps Seninesis 4:1 Extract Coriolus Mushroom/Yunzhi 20:1 Extract, 20% Polysacchrides Corus Officinals 4:1 Extract Corydalis Yanhusuo 25:1Extract, 80% Total Alkaloids (HPLC) Cranberry 10:1Extract, 10% Cranesbill 4:1 Extract Curcumae 12:1 Extract Curcumin 95% Curcuminoids

Dahurian Rhodoendron leaf 70% Proanthocyanidins (UV-VIS) Dandelion 4:1 Extract, 3% Flavonoids (HPLC) Dan-Shen (Salvia) root 8% Tansinones Devils Claw Root 4:1 Extract Dogbane 7:1 Extract Dryopeeris 15:1 Extract

Echinacea Purpurea 4% Phenolic Compounds Elderberry 5% Anthocyanidins (UV-VIS) Elecampane Flower 4:1 Extract Elecampane Root 4:1 Extract Epimedium 50% Icariin (HPLC) Eucommia Bark 20:1 Extract Eucommia Leaves 7:1 Extract Evodia 20:1 Extract Eyebright herb 4:1 Extract

Fennel Seed 4:1 Extract Fenugreek 4:1 Extract Feverfew 0.8% Parthenolide (HPLC) Fo -Ti / Ho Shou Wu, 2% Phoshatide

Ganoderma Lucidum Karst 60% Polyose Garcinia Cambogia Fruit 50% Hydroxycitric Acid Garlic 2% Allicin (HPLC) Gastrodia Rhizoma 20:1 Extract Gentian Root 10% Gentiopicroside Ginger Root 5% Gingerols Ginkgo Biloba leaf 24/6/1% Ginseng (Panax) Root 8- 80% Ginsenosides (HPLC) Golden Rod 5% Flavonoids (HPLC) Golden seal Root 5% Flavonoids (HPLC) Gotu Kola 10 - 80% Triterpenes (HPLC) Grape seed P.E.95% Anthocyanidins (UV-VIS) Grape Skin 20- 30% Polyphenols (UV-VIS) Green tea Caffeine 99% Caffeine (HPLC) Green tea Polyphenols 20%-90% (UV-VIS) Green tea ECG, EGCg 20- 99% (HPLC) Green tea L-Theanine 20- 50% (HPLC) Griffonia Seed 99% 1-5-Hydroxyiryninphan Gymnema 18:1, 25% Gymnemic Acids Gynostemma 20-90% Gypenosides (HPLC)

Inula racemosa 0.2% Alkaloids Isatis indigotica fort 60% Indirum

Jasmine tea 40% Polyphenols (UV-VIS)

Kava Kava 30% kavalactones (HPLC) Licorice Root 10% Glycyirbizic Acid (HPLC) Ligusticum 10:1 Extract Lobelia Intiata 4:1 Extract Lotus Leaf 20:1 Extract Lovage 15:1 Extract Lycium 15:1 Extract Lycoris radiata 80% Alkaloids